The Human Proteome Project (HPP) has two main directions: chromosome-based HPP (Chromosome-HPP), which focuses on annotating a subset of each chromosomal protein; and the other is a biological disease-driven HPP (bdHPP), with a purpose to answer biological questions related to the diseases.
The C-HPP program was presented by Young-Ki Paik and his team at several HUPO conferences (Amsterdam, August, 2008; Toronto, September, 2009; Sydney, September, 2010). Its primary goal: to effectively integrate proteomic data with chromosomal gene sequence information, promote more effective cooperation among global molecular biologists, and improve understanding of the biological background of proteomic data. (Hancock W. et al., J Proteome Res. 10(1), 210, 2011)
The main research module of the C-HPP program (Paik YK. et. al., Nat Biotechnology, 30(3), 221-223, 2012)
Among the 24 chromosomes, BGI is responsible for the proteome study of chromosome 20 and officially launched the study in 2012.
1. Wen B, Liu S, et al. Qualitative and quantitative expression status of the human chromosome 20 genes in cancer tissues and the representative cell lines. J Proteome Res. 2013; 12(1): 151-61.
2. Li L, Zhang Y, et al. Proteome atlas of human chromosome 8 and its multiple 8p deficiencies in tumorigenesis of the stomach, colon, and liver. J Proteome Res. 2013; 12(1): 81-8.
3. Wu S, Li N, et al. First proteomic exploration of protein-encoding genes on chromosome 1 in human liver, stomach, and colon. J Proteome Res. 2013; 12(1): 67-80.