The Yanhuang project aims to sequence 100 Chinese human genomes and construct a high-resolution genetic polymorphism map to promote medical research in China and Asia.
The results of the International Human Genome HapMap Project show that the three main populations (African, Caucasian, Asian) have a very unique haplotype structure. The Chinese population also has its own genetic background, disease susceptibility and drug response, which is very different from other population groups. For example, it is reported that Caucasians are prone to skin cancer, and Chinese are more susceptible to liver cancer. In this project, we will sequence 100 Chinese human samples and build a high-resolution genetic polymorphism map to promote medical research in Chinese and Asians. On November 6, 2008, Shenzhen BGI Life Science Research Institute (formerly “Shenzhen BGI”) published the first Asian human genome in
Nature, and announced the completion of the Yanhuang project reference genome. This is the third human genome sequenced following the DNA father James Watson and the sequencing pioneer J. Craig Venter. Currently, we have established the first Asian human genome database for data sharing and management.
Jun Wang, Wei Wang, Ruiqiang Li, et al.The diploid genome sequence of an Asian individual. Nature 2008; 456(7218): 60-5.
Li Guoqing, Song Chao, Yang Zhentao, et al.The YH database: the first Asian diploid genome database. Nucleic Acids Res 2009; 37(Database issue): D1025-8.