For the estimated 416 million people worldwide on the Alzheimer's disease continuum, including 316 million in preclinical stages, current treatment options remain frustratingly limited. While decades of research have focused on clearing amyloid beta protein deposits from the brain, this approach...
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For decades, liquid biopsy tests have analyzed the size and positioning of double-stranded cell free DNA (cfDNA) fragments in blood, but they ig-nore the single-stranded fragments that escape conventional detection. In a study published in Clinical Chemistry, scientists at BGI-Research report that c...
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The development of multicellular organisms is an extraordinarily intricate process, orchestrated by the precise interplay of genes and cells across space and time. On June 26, researchers from BGI-Research, Southern University of Science and Technology and other institutes published a groundbre...
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For more than a century, scientists have marveled at the striking disparities in regenerative ability across mammalian species. A rabbit can mend a hole punched clean through its outer ear in about a month, followed by the complete regeneration of internal structures (including cartilage, blood...
Early mammalian development unfolds in millimetre-sized embryos within hours, yet errors during this brief window cause nearly a third of all birth defects, from congenital heart disease to neural tube malformations. Using BGI's high-resolution Stereo-seq spatial transcriptomics, an internationa...
When scientists examine a slice of tumor tissue under the microscope, they see only part of the story. Gene activity, cellular architecture, and the precise location of each cell weave together a complex tapestry that determines how a cancer grows, spreads, and responds to therapy. Existing software...
Ants march across almost every terrestrial habitat, from scorching dunes to rainforest canopies, yet their real triumph lies in the way each colony functions as a tightly cho-reographed "superorganism" whose sterile workers labour for a single reproductive queen. What underpins their extra...
Intracerebral hemorrhage (ICH) may account for barely one in seven strokes, yet it is the deadliest form: more than forty percent of patients die within days and many survivors never walk or speak independently again. Clinicians know that blood leaking into the brain sets off waves of inflammation, ...
When a new lung is sewn into a patient, the first 72 hours are a knife edge: approximately 15% to 25% of recipients develop severe primary graft dysfunction (PGD), an explosive form of sterile inflammation that floods the graft with fluid and starves it of oxygen, representing the principal cause of...